马飞贺，博士，研究员。2012年本科毕业于天津大学化工学院，2015年和2018年于南开大学分别获得有机化学硕士学位（导师：苏循成教授）和高分子化学与物理博士学位（导师：史林启教授），2018.10-2020.11月在美国Tufts University生物医学工程系进行博士后研究工作（合作导师：Qiaobing Xu教授），2021年3月加入十大正规赌官方网站，2021年12月晋升为研究员。主要研究方向为生物医用高分子材料，并探究其在肿瘤、脑疾病和细菌感染治疗等方面的应用。

联系方式：

E-mail：feihema@tiangong.edu.cn；

地址：天津市西青区宾水西道399号十大正规赌官方网站6B325；邮编：300387。

研究方向：

1. 生物医用高分子材料

2. 蛋白质折叠调控与递送

3. 脑靶向纳米药物

主持或参加的国家自然科学基金项目/课题：

1. 国家自然科学基金委员会, 面上项目, 52373153, 蛋白折叠调控高分子纳米载体介导去折叠细胞因子的重折叠与递送, 2024-01-01 至 2027-12-31, 50万元, 在研, 主持

2. 国家自然科学基金委员会, 青年科学基金项目, 52103180, 基于神经递质的脑部递送体系的构建, 2022-01-01 至 2024-12-31, 30万元, 在研, 主持

3. 国家自然科学基金委员会, 面上项目, 51773098, 高分子量聚缩酮的制备、性能表征及其生物医学应 用的研究, 2018-01-01 至 2021-12-31, 61万元, 结题, 参与

4. 国家自然科学基金委员会, 国际(地区)合作与交流项目, 21620102005, 抗细菌生物被膜感染的自适应 多功能投递系统, 2017-01-01 至 2021-12-31, 214万元, 结题, 参与

5. 国家自然科学基金委员会, 青年科学基金项目, 51603105, 葡萄糖响应性水凝胶-胶束复合载体协同释 放胰岛素和二甲双胍, 2017-01-01 至 2019-12-31, 20万元, 结题, 参与

近5年内发表的5篇代表性论著：

（1）Yang Menglin; Zhang Yanli; Deng Fei; Wu Xiaohui; Chen Yujie; Ma Feihe*; Shi Linqi*; Development of self-cooperative nanochaperones with enhanced activity to facilitate protein refolding, Materials Horizons, 2023, Accepted

（2） Wu Xiaohui; Ma Feihe*; Pan Bin-Bin; Zhang Yanli; Zhu Lin; Deng Fei; Xu Linlin; Zhao Yu; Yin Xu; Niu Haihong; Su Xun-Cheng*; Shi Linqi*; Tailoring a nanochaperone to regulate α-synuclein assembly, Angewandte Chemie International Edition, 2022, 61: e202200192.

（3） Ma Feihe^#; Wu Xiaohui^#; Li Ang; Xu Linlin; An Yingli; Shi Linqi*; A balance between capture and release: how nanochaperones regulate refolding of thermally denatured proteins, Angewandte Chemie International Edition, 2021, 60: 10865-10870.

（4） Ma Feihe^#; Yang liu^#; Sun Zhuorui; Chen Jinjin; Rui Xuehui; Glass Zachary; Xu Qiaobing*; Neurotransmitter-derived lipidoids （NT-lipidoids） for enhanced brain delivery through intravenous injection, Science Advances, 2020, 6: eabb4429.

（5） Ma Fei-He; Li Chang; Liu Yang; Shi Linqi *; Mimicking molecular chaperones to regulate protein folding, Advanced Materials, 2020, 32: 1805945.

已发表的其他论著：

（1） Zhang Yongxin; Chen Jiajing; Shi Linqi *; Ma Feihe*; Polymeric nanoparticle-based nanovaccines for cancer immunotherapy. Materials Horizons, 2023, 10: 361-392.

（2）Wu Xiaohui; Deng Fei; Chen Yujie; Xu Mengchen; Ma Feihe*; Shi Linqi*; Electrostatic and hydrophobic interaction cooperative nanochaperone regulates protein folding, Aggregate, 2023, Accepted

（3） Zhang Yongxin; Fu Hao; Chen Jiajing; Xu Linlin; An Yingli; Ma Rujiang; Zhu Chunlei; Liu Yang; Ma Feihe*; Shi Linqi*; Holdase/Foldase mimetic nanochaperone improves antibody-based cancer immunotherapy, Small Methods, 2023, 7: 2201051.

（4） Chen Jiajing; Xu Mengchen; Zhang Yongxin; Xu Linlin; Zhao Shuyue; An Yingli; Ma Rujiang; Liu Yang; Ma Feihe*; Shi Linqi*; Allosteric synthetic antibody (Allo-SyAb) for improved cancer immunotherapy, Chemical Engineering Journal, 2023, 463: 142374.

（5） Xin Youtao; Wang Luyao; Chang Huanghuang; Ma Feihe*; Sun Minglei; Chen Li; Gao Hui*; Construction of PAMAM-based nanocomplex conjugated with Pt(IV)-complex and lauric acid exerting both anti-tumor and antibacterial effects, Chinese Journal of Polymer Science, 2023, 41: 887–896.

（6） Li Xiaohui; Ma Yanmei; Xin Youtao; Ma Feihe; Gao Hui*; Tumor-targeting nanoassembly for enhanced colorectal cancer therapy by eliminating intratumoral Fusobacterium nucleatum; ACS Applied Materials & Interfaces, 2023, 15: 14164-14172

（7） Li Xue; Zhang Yongxin; Wu Xiaohui; Chen Jiajing; Yang Menglin; Ma Feihe*; Shi Linqi*; In situ antigen‐capturing nanochaperone toward personalized nanovaccine for cancer immunotherapy, Small, 2022, 2203100.

（8） Yan Xiangjie; Ma Feihe; Qixian Chen; Gou Xiangbo; Li Xiaohui, Zhang Liuwei, Gao Hui*; Construction of size-transformable supramolecular nano-platform against drug-resistant colorectal cancer caused by Fusobacterium nucleatum, Chemical Engineering Journal, 2022, 137605.

（9） Deng Fei; Yang Menglin; Zhang Yanli; Wu Xiaohui; Ma Rujiang; Ma Feihe*; Shi Linqi*; One-pot synthesis of high-concentration mixed-shell polymeric micelles as nanochaperones for the renaturation of bulk proteins, Polymer Chemistry, 2022, 13: 914-921.

（10） Xu Linlin; Ding Yuxun; Ma Feihe; Chen Yue; Chen Guidong; Zhu Lin; Long Jiafu; Ma Rujiang; Liu Yang; Liu Jianfeng; Huang Fan*; Shi Linqi*; Engineering a pathological tau-targeted nanochaperone for selective and synergetic inhibition of tau pathology in Alzheimer's Disease, Nano Today, 2022, 43: 101388.

（11） Hershman Rebecca L; Li Yamin; Ma Feihe; Xu Qioabing; Van Deventer James*; Intracellular delivery of antibodies for selective cell signaling interference, ChemMedChem, 2022, 17: e202100678.

（12） Chen Jinjin; Qiu Min; Ma Feihe; Yang Liu; Glass Zachary; Xu Qiaobing*; Enhanced protein degradation by intracellular delivery of pre-fused PROTACs using lipid-like nanoparticles, Journal of Controlled Release, 2021, 330: 1244-1249.

（13） Yang Liu; Ma Feihe; Zhao Xuewei; Liu Fang; Chen Jinjin; Xu Qiaobing*; Efficient delivery of antisense oligonucleotides using bioreducible lipid nanoparticles in vitro and in vivo, Molecular Therapy. Nucleic Acids, 2020, 19: 1357-1367.

（14） Liu Fang; Yang Liu; Li Yamin; Junier Ashlee; Ma Feihe; Chen Jinjin; Han Haobo; Glass Zachary; Zhao Xuewei; Kumamoto Carol A.; Sang Hong*; Xu Qiaobing*; In vitro and in vivo study of an Amphotericin B formulation with quaternized bioreducible lipidoids, ACS Biomaterials Science & Engineering, 2020, 6: 1046-1073.

（15） Zhao Yu; Cai Jinquan; Liu Zichen; Li Yansheng; Zheng Chunxiong; Zheng Yadan; Chen Qun; Chen Hongyun; Ma Feihe; An Yingli; Xiao Lehui; Jiang Chuanlu; Shi Linqi*; Kang Chunsheng*; Liu Yang*; Nano-composites inhibit the formation, mitigate the neurotoxicity and facilitate the removal of β-amyloid aggregates in Alzheimer's disease mice, Nano Letters, 2018, 19: 674-683.

（16） Ma Fei-He; An Yingli; Wang Jianzu; Song Yiqing; Liu Yang; Shi Linqi* ; Synthetic nanochaperones facilitate refolding of denatured proteins, ACS Nano, 2017, 11: 10549-10557

（17） Ma Fei-He; Wang Xiao; Chen Jia-Liang; Wen Xin; Sun Han; Su Xun-Cheng*; Deciphering the multisite interactions of a protein and its ligand at atomic resolution by using sensitive paramagnetic effects, Chemistry - A European Journal, 2017, 23: 926-934.

（18） Ma Fei-He; Chen Jia-Liang; Li Qing-Feng; Zuo Hui-Hui; Huang Feng; Su Xun-Cheng ; Kinetic assay of the michael addition-like thiol-ene reaction and insight into protein bioconjugation, Chemistry-An Asian Journal, 2014, 9: 1808-1816.